Итак, начнем:

нам понадобится установленный пакет virtualenv

virtualenv $DOC_ROOT
cd $DOC_ROOT/bin
./easy_install django
cp /var/www/wsgi_app.py $DOC_ROOT/$pypath/
nano /$DOC_ROOT/$pypath/wsgi_app.py #edit PATH_PROJECT to fit your needs

wsgi_app.py listing:

import os, sys                                                                                                                                        
PATH_BASE = os.path.dirname(os.path.dirname(os.path.abspath(__file__)))                                                                               
PATH_PROJECT = os.path.join(PATH_BASE, 'pyprojectname')                                                                                                                         
activate_this = os.path.join(PATH_BASE, 'bin/activate_this.py')                                                                                       
execfile(activate_this, dict(__file__=activate_this))                                                                                                 
                                                                                                                                                      
sys.path.append(PATH_PROJECT)                                                                                                                         
sys.path.append(PATH_BASE)                                                                                                                            
                                                                                                                                                      
os.environ['DJANGO_SETTINGS_MODULE'] = 'settings'                                                                                                     
                                                                                                                                                      
import django.core.handlers.wsgi                                                                                                                      
application = django.core.handlers.wsgi.WSGIHandler()

nginx sample config:

server {                                                                                                                                              
    listen 80;                                                                                                                                        
    server_name sitename.name www.sitename.name;                                                                                                        
    location / {                                                                                                                                      
                uwsgi_pass unix:///var/run/uwsgi.socket;                                                                                              
                include uwsgi_params;                                                                                                                 
                uwsgi_param UWSGI_CHDIR /var/www/sitename.name/pypath;                                                                                  
                uwsgi_param UWSGI_PYHOME /var/www/sitename.name/;                                                                                      
                uwsgi_param UWSGI_SCRIPT wsgi_app;                                                                                                    
                }                                                                                                                                     
    location ~* \.(jpg|gif|png|css|js|swf)$ {                                                                                                             
                root /var/www/sitename.name/pypath/media/;                                                                                                    
                }                                                                                                                                         
    }